Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma.

@article{Zamolodchikov2015ActivationOT,
  title={Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma.},
  author={Daria Zamolodchikov and Zu-Lin Chen and Brooke A. Conti and Thomas Renn{\'e} and Sidney Strickland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 13},
  pages={4068-73}
}
Alzheimer's disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ), which likely contributes to disease via multiple mechanisms. Increasing evidence implicates inflammation in AD, the origins of which are not completely understood. We investigated whether circulating Aβ could initiate inflammation in AD via the plasma contact activation system. This proteolytic cascade is triggered by the activation of the plasma protein factor XII (FXII) and leads to kallikrein-mediated… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS
14 Citations
54 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

The FXII-driven Plasma Contact System. Hemostasis and Thrombosis

  • T Renné
  • Basic Princeples and Clinical Practice,
  • 2013
1 Excerpt

The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice

  • MH Ou-Yang, WE Van Nostrand
  • J Neuroinflammation
  • 2013
1 Excerpt

Similar Papers

Loading similar papers…