Activation of the erythrocyte plasma membrane redox system by resveratrol: a possible mechanism for antioxidant properties.

@article{Rizvi2010ActivationOT,
  title={Activation of the erythrocyte plasma membrane redox system by resveratrol: a possible mechanism for antioxidant properties.},
  author={Syed Ibrahim Rizvi and Kanti Bhooshan Pandey},
  journal={Pharmacological reports : PR},
  year={2010},
  volume={62 4},
  pages={
          726-32
        }
}
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49 Citations

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TLDR
This work investigates the underlying mechanism triggered by RWp in the activation of PMRS via the involvement of intracellular GSH and concludes that the pro-oxidant effect of RWp promotes an adaptive stress response in human erythrocytes, which improves their antioxidant defense protecting them from oxidative stress.
Resveratrol up-regulates the erythrocyte plasma membrane redox system and mitigates oxidation-induced alterations in erythrocytes during aging in humans.
TLDR
Experimental evidence is provided that resveratrol confers ability to up-regulate the plasma membrane redox system (PMRS) along with ascorbate free radical reductase, a compensatory system operating in the cell to maintain cellular redox state, and findings suggest a possible role of resver atrol in retardation of age-dependent oxidative stress.
Red wine activates plasma membrane redox system in human erythrocytes
TLDR
It is reported that polyphenols present in red wine obtained by a controlled microvinification process are able to protect human erythrocytes from oxidative stress and to activate Plasma Membrane Redox System (PMRS).
Protective effects of resveratrol against hypoxanthine-xanthine oxidase-induced toxicity on human erythrocytes
In Vitro Cell-Mediated Antioxidant Protection of Human Erythrocytes by Some Common Tropical Fruits
The semi-automated erythrocyte cellular antioxidant activity (ERYCA) method and Hydrophilic Oxygen Radical Absorbance Capacity (H-ORAC) assay were used to assess the ability of aqueous acetone…
The Influence of Oxidative Stress and Natural Antioxidants on Morphometric Parameters of Red Blood Cells, the Hemoglobin Oxygen Binding Capacity, and the Activity of Antioxidant Enzymes
Using a wide range of different physical and chemical methods, it was found that the oxidative stress caused by addition of hydrogen peroxide to the incubation medium has a significant effect on the…
Acetaldehyde-induced oxidative modifications and morphological changes in isolated human erythrocytes: an in vitro study
TLDR
The results show that acetaldehyde enhances the generation of ROS and RNS that results in oxidative modification of cellular components that will lower the oxygen transporting ability of blood and shorten erythrocyte lifespan (red cell senescence).
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