Activation of the erythrocyte plasma membrane redox system by resveratrol: a possible mechanism for antioxidant properties.

  title={Activation of the erythrocyte plasma membrane redox system by resveratrol: a possible mechanism for antioxidant properties.},
  author={Syed Ibrahim Rizvi and Kanti Bhooshan Pandey},
  journal={Pharmacological reports : PR},
  volume={62 4},

Figures from this paper

Modulation of Erythrocyte Plasma Membrane Redox System Activity by Curcumin
Results suggest that curcumin interacts with amino acids at the active site cavity of cytochrome b 5 reductase, a key constituent of PMRS, and increased the GSH level in erythrocytes and plasma while simultaneously decreasing the oxidant potential (PFEOP) of plasma.
The Pro-Oxidant Activity of Red Wine Polyphenols Induces an Adaptive Antioxidant Response in Human Erythrocytes
It is concluded that the pro-oxidant effect of RWp promoted an adaptive stress response in human erythrocytes, which enhances their antioxidant defense, protecting them against oxidative stress.
Plant polyphenols as electron donors for erythrocyte plasma membrane redox system: validation through in silico approach
Comparisons of docking simulation and pharmacophoric features show that novel potent molecules can be designed with higher efficacy for activation of the PMRS system, and show the presence of minimum bioactive component in all the selected polyphenols.
A new role of red wine in modulating erythrocytes antioxidant defense
This work investigates the underlying mechanism triggered by RWp in the activation of PMRS via the involvement of intracellular GSH and concludes that the pro-oxidant effect of RWp promotes an adaptive stress response in human erythrocytes, which improves their antioxidant defense protecting them from oxidative stress.
Resveratrol up-regulates the erythrocyte plasma membrane redox system and mitigates oxidation-induced alterations in erythrocytes during aging in humans.
Experimental evidence is provided that resveratrol confers ability to up-regulate the plasma membrane redox system (PMRS) along with ascorbate free radical reductase, a compensatory system operating in the cell to maintain cellular redox state, and findings suggest a possible role of resver atrol in retardation of age-dependent oxidative stress.
Red wine activates plasma membrane redox system in human erythrocytes
It is reported that polyphenols present in red wine obtained by a controlled microvinification process are able to protect human erythrocytes from oxidative stress and to activate Plasma Membrane Redox System (PMRS).
In Vitro Cell-Mediated Antioxidant Protection of Human Erythrocytes by Some Common Tropical Fruits
The semi-automated erythrocyte cellular antioxidant activity (ERYCA) method and Hydrophilic Oxygen Radical Absorbance Capacity (H-ORAC) assay were used to assess the ability of aqueous acetone
The Influence of Oxidative Stress and Natural Antioxidants on Morphometric Parameters of Red Blood Cells, the Hemoglobin Oxygen Binding Capacity, and the Activity of Antioxidant Enzymes
Using a wide range of different physical and chemical methods, it was found that the oxidative stress caused by addition of hydrogen peroxide to the incubation medium has a significant effect on the
Acetaldehyde-induced oxidative modifications and morphological changes in isolated human erythrocytes: an in vitro study
The results show that acetaldehyde enhances the generation of ROS and RNS that results in oxidative modification of cellular components that will lower the oxygen transporting ability of blood and shorten erythrocyte lifespan (red cell senescence).


Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity
The present data show a relationship between the flavonoid structures and their ability to provide electrons to the PMOR, suggesting an additional mechanism whereby dietary flavonoids may exert beneficial effects in man.
Erythrocyte plasma membrane redox system in human aging.
The authors hypothesize that the increased PMRS in erythrocytes during aging may be a protective mechanism of the system for efficient extracellular DHA reduction and ascorbate recycling under condition of increased oxidative stress.
Extracellular reduction of the ascorbate free radical by human erythrocytes.
The results suggest that erythrocytes spare extracellular ascorbate by enhancing recycling of the AFR, which could help to maintain ext racellular concentrations of the vitamin.
Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes.
Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses.