Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation

@article{Ruan2012ActivationOT,
  title={Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation},
  author={Ye Chun Ruan and Jing Guo and Xinmei Liu and Runju Zhang and Lai Ling Tsang and Jian Dong and Hui Chen and Mei Yu and Xiaohua Jiang and Xiao Hu Zhang and K. L. B. Fok and Yiu Wa Chung and Hefeng Huang and Wen Liang Zhou and Hsiao Chang Chan},
  journal={Nature Medicine},
  year={2012},
  volume={18},
  pages={1112-1117}
}
Embryo implantation remains a poorly understood process. We demonstrate here that activation of the epithelial Na+ channel (ENaC) in mouse endometrial epithelial cells by an embryo-released serine protease, trypsin, triggers Ca2+ influx that leads to prostaglandin E2 (PGE2) release, phosphorylation of the transcription factor CREB and upregulation of cyclooxygenase 2, the enzyme required for prostaglandin production and implantation. We detected maximum ENaC activation, as indicated by ENaC… CONTINUE READING