Activation of the epithelial Na+ channel in the collecting duct by vasopressin contributes to water reabsorption.

@article{Bugaj2009ActivationOT,
  title={Activation of the epithelial Na+ channel in the collecting duct by vasopressin contributes to water reabsorption.},
  author={Vladislav Bugaj and Oleh M. Pochynyuk and James D Stockand},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={297 5},
  pages={F1411-8}
}
We used patch-clamp electrophysiology on isolated, split-open murine collecting ducts (CD) to test the hypothesis that regulation of epithelial sodium channel (ENaC) activity is a physiologically important effect of vasopressin. Surprisingly, this has not been tested directly before. We ask whether vasopressin affects ENaC activity distinguishing between acute and chronic effects, as well as, parsing the cellular signaling pathway and molecular mechanism of regulation. In addition, we… CONTINUE READING
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