Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of heme oxygenase 1 (HO-1)

@inproceedings{AbdelbasetIsmail2017ActivationOT,
  title={Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of heme oxygenase 1 (HO-1)},
  author={Ahmed Abdelbaset-Ismail and Sylwia Borkowska-Rzeszotek and Ewa Kubiś and Kamila Bujko and Katarzyna Brzeźniakiewicz-Janus and Lukasz Bolkun and Janusz Kloczko and Marcin Moniuszko and Grzegorz W Basak and Wieslaw Wiktor-Jedrzejczak and Mariusz Z Ratajczak},
  booktitle={Leukemia},
  year={2017}
}
As a crucial arm of innate immunity, the complement cascade (ComC) is involved both in mobilization of normal hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM) into peripheral blood and in their homing to BM. Despite the fact that ComC cleavage fragments alone do not chemoattract normal HSPCs, we found that leukemia cell lines as well as… CONTINUE READING