Activation of the coagulation mechanism on tumor necrosis factor-stimulated cultured endothelial cells and their extracellular matrix. The role of flow and factor IX/IXa.

@article{Tijburg1991ActivationOT,
  title={Activation of the coagulation mechanism on tumor necrosis factor-stimulated cultured endothelial cells and their extracellular matrix. The role of flow and factor IX/IXa.},
  author={P N Tijburg and Jean M Ryan and David M. Stern and B Wollitzky and S. Rimon and Abraham Rimon and Dan Handley and Peter P Nawroth and Jan J. Sixma and Philip G. de Groot},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 18},
  pages={12067-74}
}
Infusion of tumor necrosis factor (TNF) into tumor-bearing mice led to intravascular clot formation with fibrin deposition in microvessels in the tumor bed in close association with the vessel wall, which could be prevented by active site-blocked factor IXa (IXai). This observation prompted us to examine the role of the intrinsic system in activation of the… CONTINUE READING