Activation of the cholinergic antiinflammatory pathway ameliorates obesity-induced inflammation and insulin resistance.

Abstract

Obesity is associated with a chronic inflammatory state characterized by adipose tissue macrophage infiltration and inflammation, which contributes to insulin resistance. The cholinergic antiinflammatory pathway, which acts through the macrophage α7-nicotinic acetylcholine receptor (α7nAChR), is important in innate immunity. Here we show that adipose tissue… (More)
DOI: 10.1210/en.2010-0855

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