Activation of the cell death program by inhibition of proteasome function.

@article{Drexler1997ActivationOT,
  title={Activation of the cell death program by inhibition of proteasome function.},
  author={Hannes C. A. Drexler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 3},
  pages={
          855-60
        }
}
Activation of proteolytic enzymes, including cysteine proteases of the ced-3/ICE family, is a characteristic feature of the apoptotic program. In contrast, the role of the proteasome as the major nonlysosomal machinery to degrade or process proteins by ATP/ubiquitin-dependent proteolysis in this process is less clear. In human leukemic HL60 cells, inhibition of proteasome-mediated proteolysis by specific proteasomal inhibitors leads to the rapid induction of apoptosis as judged by morphological… CONTINUE READING

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