Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.

  title={Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.},
  author={Kevin G Hardwick and Elizabeth Weiss and Francis C. Luca and Mark Winey and Andrew W. Murray},
  volume={273 5277},
The spindle assembly checkpoint keeps cells with defective spindles from initiating chromosome segregation. The protein kinase Mps1 phosphorylates the yeast protein Mad1p when this checkpoint is activated, and the overexpression of Mps1p induces modification of Mad1p and arrests wild-type yeast cells in mitosis with morphologically normal spindles. Spindle assembly checkpoint mutants overexpressing Mps1p pass through mitosis without delay and can produce viable progeny, which demonstrates that… CONTINUE READING
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