Activation of the brain 5-HT2C receptors causes hypolocomotion without anxiogenic-like cardiovascular adjustments in mice.

@article{Stiedl2007ActivationOT,
  title={Activation of the brain 5-HT2C receptors causes hypolocomotion without anxiogenic-like cardiovascular adjustments in mice.},
  author={Oliver Stiedl and Ilga Misane and M{\'e}lanie Koch and Tommy Pattij and Michael Meyer and Sven Ove {\"O}gren Ogren},
  journal={Neuropharmacology},
  year={2007},
  volume={52 3},
  pages={949-57}
}
The present study evaluated whether hypolocomotion elicited by subcutaneous administration of the non-specific 5-HT/preferential 5-HT(2C) receptor agonist mCPP during novelty exposure was due to an enhanced anxiety-like state. The effects of mCPP on exploratory behavior during exposure to a new environment (novelty) were studied in male C57BL/6N mice. Subcutaneous injection of mCPP (1 and 3mg/kg) and the preferential 5-HT(2C) receptor agonist MK212 (0.7 and 1mg/kg) induced hypolocomotion during… CONTINUE READING
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