Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice.

@article{Johnson2002ActivationOT,
  title={Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice.},
  author={Dianna A. Johnson and G. K. Andrews and Weili Xu and Jeffrey A. Johnson},
  journal={Journal of neurochemistry},
  year={2002},
  volume={81 6},
  pages={
          1233-41
        }
}
Many phase II protective genes contain a cis -acting enhancer region known as the antioxidant response element (ARE). Increased expression of these genes contributes to the protection of cells from oxidative stress. Transgenic reporter mice were created that carry in their genome the core ARE coupled to the human placental alkaline phosphatase (hPAP) reporter gene. Primary cortical cultures derived from these mice were treated with tBHQ resulting in a dose-dependent increase in hPAP activity… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 70 CITATIONS

FILTER CITATIONS BY YEAR

2003
2017

CITATION STATISTICS

  • 13 Highly Influenced Citations

  • Averaged 2 Citations per year over the last 3 years

Similar Papers

Loading similar papers…