Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.

@article{Kuo2006ActivationOT,
  title={Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.},
  author={Yien Lik Kuo and Chou-Zen Giam},
  journal={The EMBO journal},
  year={2006},
  volume={25 8},
  pages={
          1741-52
        }
}
The human T-lymphotropic virus type 1 (HTLV-1) Tax binds the anaphase promoting complex (APC) and activates it ahead of schedule. Here, we show that APC activation by Tax induces rapid senescence (tax-IRS) independently of p53 and pRB. In response to tax, cyclin A, cyclin B1, securin, and Skp2 becomes polyubiquitinated and degraded starting in S phase. This is followed by a surge in p21(CIP1/WAF1) and p27(KIP1) in mid to late S and G2/M leading to a permanent G1 arrest. Tax-positive HTLV-1… CONTINUE READING
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