Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells.

@article{Shan2013ActivationOT,
  title={Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells.},
  author={Jixiu Shan and Takashi Hamazaki and Tiffany A. Tang and Naohiro Terada and Michael S. Kilberg},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2013},
  volume={305 3},
  pages={E325-35}
}
In somatic cells, a collection of signaling pathways activated by amino acid limitation have been identified and referred to as the amino acid response (AAR). Despite the importance of possible detrimental effects of nutrient limitation during in vitro culture, the AAR has not been investigated in embryonic stem cells (ESC). AAR activation caused the… CONTINUE READING