Activation of the action potential Na+ ionophore by neurotoxins. An allosteric model.

@article{Catterall1977ActivationOT,
  title={Activation of the action potential Na+ ionophore by neurotoxins. An allosteric model.},
  author={William A. Catterall},
  journal={The Journal of biological chemistry},
  year={1977},
  volume={252 23},
  pages={8669-76}
}
The alkaloid neurotoxins aconitine, veratridine, grayanotoxin, and batrachotoxin activate the action potential Na+ ionophore by interaction with a common binding site. Concentration-response curves are fit by simple Langmuir isotherms. The fraction of Na+ ionophores activated at saturating concentrations of neurotoxin are: aconitine, 0.02; veratridine, 0.08; grayanotoxin, 0.51; and batrachotoxin, 0.95. The concentrations required to obtain 50% of the maximum activation are: aconitine, 3.6 x… CONTINUE READING
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References

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Showing 1-5 of 5 references

inlon Transport Across Membranes - The Proceedings of a Joint U . S . - USSR Conference , (

  • B. I. Khodorov
  • 1977

Biophysics and Physiology ofExcitable Membranes

  • D. T. Campbell, B. Hille
  • J. Gen. Physiol
  • 1976

Pflugers Archiu

  • D. C. Tosteson, Y. A. Ovchinnikov, H. Schmidt, 0. Schmitt
  • Gesamte Physiol . Menschen Tiere
  • 1974

Ergeb

  • W. Ulbricht
  • Physiol . Biol . Chem . Exp . Pharmakol .
  • 1969

Helu . Physiol . Pharmacol

  • R. Straub
  • Acta
  • 1956

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