Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation.

@article{Brogi2017ActivationOT,
  title={Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation.},
  author={Simone Brogi and Samuele Maramai and Margherita Brindisi and Giulia Chemi and Valentina Porcari and Claudio Corallo and L Gennari and Ettore Novellino and Anna Ramunno and Stefania Butini and Giuseppe Campiani and Sandra Gemma},
  journal={ChemMedChem},
  year={2017},
  volume={12 24},
  pages={2074-2085}
}
A computational analysis of the X-ray structure of the low-density lipoprotein receptor-related protein 6 (LRP6) with the Dickkopf-1 (DKK1) C-terminal fragment has allowed us to rationally design a small set of decapeptides. These compounds behave as agonists of the canonical Wnt pathway in the micromolar range when tested on a dual luciferase Wnt… CONTINUE READING