Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis.

@article{Yuan2014ActivationOT,
  title={Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis.},
  author={Ke Yuan and Mark E Orcholski and Cristina Panaroni and Eric M Shuffle and Ngan F Huang and Xinguo Jiang and Wen Tian and Eszter K Vladar and Lingli Wang and Mark R Nicolls and Joy Y Wu and Vinicio de Jesus Perez},
  journal={The American journal of pathology},
  year={2014},
  volume={185 1},
  pages={
          69-84
        }
}
Pericytes are perivascular cells localized to capillaries that promote vessel maturation, and their absence can contribute to vessel loss. Whether impaired endothelial-pericyte interaction contributes to small vessel loss in pulmonary arterial hypertension (PAH) is unclear. Using 3G5-specific, immunoglobulin G-coated magnetic beads, we isolated pericytes from the lungs of healthy subjects and PAH patients, followed by lineage validation. PAH pericytes seeded with healthy pulmonary microvascular… CONTINUE READING
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