Activation of the WNT/β-catenin pathway attenuates experimental emphysema.

  title={Activation of the WNT/β-catenin pathway attenuates experimental emphysema.},
  author={Nikolaus Kneidinger and Ali Oender Yildirim and Jens Callegari and Shinji Takenaka and Maria Stein and Rio Dumitrascu and Alexander Bohla and Ken R Bracke and Rory E Morty and Guy G Brusselle and Ralph Theo Schermuly and Oliver Eickelberg and Melanie K{\"o}nigshoff},
  journal={American journal of respiratory and critical care medicine},
  volume={183 6},
RATIONALE Chronic obstructive pulmonary disease (COPD) is a devastating disease, for which no causal therapy is available. OBJECTIVES To characterize WNT/β-catenin signaling in COPD in humans and elucidate its potential role as a preventive and therapeutic target in experimental emphysema in mice. METHODS The expression, localization, and activity of WNT/β-catenin signaling was assessed in 12 COPD and 12 transplant donor samples using quantitative reverse transcriptase polymerase chain… CONTINUE READING


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