Activation of the TREM-1 pathway in human monocytes by periodontal pathogens and oral commensal bacteria.

@article{Varanat2017ActivationOT,
  title={Activation of the TREM-1 pathway in human monocytes by periodontal pathogens and oral commensal bacteria.},
  author={Mrudula Varanat and E M Haase and Jason G. Kay and F. Scannapieco},
  journal={Molecular oral microbiology},
  year={2017},
  volume={32 4},
  pages={275-287}
}
Periodontitis is a highly prevalent disease caused in part by an aberrant host response to the oral multi-species biofilm. A balance between the oral bacteria and host immunity is essential for oral health. Imbalances in the oral microbiome lead to an uncontrolled host inflammatory response and subsequent periodontal disease (i.e. gingivitis and periodontitis). TREM-1 is a signaling receptor present on myeloid cells capable of acting synergistically with other pattern recognition receptors… CONTINUE READING