Activation of the Src family kinase Hck without SH3-linker release.

@article{Lerner2005ActivationOT,
  title={Activation of the Src family kinase Hck without SH3-linker release.},
  author={Edwina C. Lerner and Ronald P Trible and Anthony P. Schiavone and James M Hochrein and John R. Engen and Thomas E Smithgall},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 49},
  pages={40832-7}
}
Src family protein-tyrosine kinases are regulated by intramolecular binding of the SH2 domain to the C-terminal tail and association of the SH3 domain with the SH2 kinase-linker. The presence of two regulatory interactions raises the question of whether disruption of both is required for kinase activation. To address this question, we engineered a high… CONTINUE READING