Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.

@article{Chin1997ActivationOT,
  title={Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.},
  author={Y Eugene Chin and Masatoshi Kitagawa and Keisuke Kuida and Richard A Flavell and Xiao Yan Fu},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 9},
  pages={5328-37}
}
Protein tyrosine kinases activate the STAT (signal transducer and activator of transcription) signaling pathway, which can play essential roles in cell differentiation, cell cycle control, and development. However, the potential role of the STAT signaling pathway in the induction of apoptosis remains unexplored. Here we show that gamma interferon (IFN-gamma) activated STAT1 and induced apoptosis in both A431 and HeLa cells, whereas epidermal growth factor (EGF) activated STAT proteins and… CONTINUE READING
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