Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease

@inproceedings{Shan2015ActivationOT,
  title={Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease},
  author={Wen Shan and Lili Gao and Wenjing Zeng and Yan Feng Hu and Gang Wang and Mingzhu Li and Junjun Zhou and Xiao-dong Ma and Xiaofeng Tian and Jihong Yao},
  booktitle={Cell Death and Disease},
  year={2015}
}
Recent studies have demonstrated that miR-34a expression is significantly upregulated and associated with apoptosis in nonalcoholic fatty liver disease (NAFLD). Carnosic acid (CA) is a novel antioxidant and a potential inhibitor of apoptosis in organ injury, including liver injury. This study aimed to investigate the signaling mechanisms underlying miR-34a… CONTINUE READING