Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia

@article{Martinelli2016ActivationOT,
  title={Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia},
  author={Giulia Benedetta Martinelli and Davide Olivari and Agnese Cecconi and Laura Talamini and Linda Ottoboni and Stewart H. Lecker and C. T. Stretch and Vickie Baracos and Oliver F Bathe and Andrea Resovi and Raffaella Giavazzi and Luigi Cervo and Rosanna Piccirillo},
  journal={Oncogene},
  year={2016},
  volume={35},
  pages={6212-6222}
}
Cancer cachexia is a life-threatening syndrome that affects most patients with advanced cancers and causes severe body weight loss, with rapid depletion of skeletal muscle. No treatment is available. We analyzed microarray data sets to identify a subset of genes whose expression is specifically altered in cachectic muscles of Yoshida hepatoma-bearing rodents but not in those with diabetes, disuse, uremia or fasting. Ingenuity Pathways Analysis indicated that three genes belonging to the C-X-C… CONTINUE READING
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