Activation of the RON receptor tyrosine kinase protects murine macrophages from apoptotic death induced by bacterial lipopolysaccharide.

@article{Chen2002ActivationOT,
  title={Activation of the RON receptor tyrosine kinase protects murine macrophages from apoptotic death induced by bacterial lipopolysaccharide.},
  author={Yi-qing Chen and Yong-qing Zhou and Ming-Hai Wang},
  journal={Journal of leukocyte biology},
  year={2002},
  volume={71 2},
  pages={359-66}
}
RON is a receptor tyrosine kinase activated by macrophage-stimulating protein. We demonstrate here that RON activation inhibits LPS-induced apoptosis of mouse peritoneal macrophages and Raw264.7 cells expressing RON or a constitutively active RON mutant. The antiapoptotic effect of RON was accompanied with the inhibition of LPS-induced production of nitric oxide (NO), a molecule responsible for LPS-induced cell apoptosis. This conclusion is supported by experiments using a chemical NO donor… CONTINUE READING

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Activation of the cell death program by nitric oxide involves inhibition of the proteasome

  • S. Glockzin, A. von Knethen, M. Scheffner, B. Brune
  • J. Biol
  • 1999
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