Activation of the RAGE pathway: a general mechanism in the pathogenesis of polyneuropathies?

@article{Haslbeck2007ActivationOT,
  title={Activation of the RAGE pathway: a general mechanism in the pathogenesis of polyneuropathies?},
  author={Karl Matthias Haslbeck and Bernhard Neundoerfer and Ursula Schl{\"o}tzer-Schrehardtt and Angelika Bierhaus and Erwin D. Schleicher and Elisabeth Pauli and Manfred Haslbeck and Martin Hecht and Peter P Nawroth and Dieter Heuss},
  journal={Neurological research},
  year={2007},
  volume={29 1},
  pages={103-10}
}
OBJECTIVES Binding of ligands to the receptor for advanced glycation end products (RAGE) results in activation of the transcription factor NF-kappaB and subsequent expression of NF-kappaB regulated cytokines and is a possible pathomechanism in diabetic and in vasculitic polyneuropathies (PNP). We wanted to investigate whether the newly discovered RAGE pathway also contributes to the pathogenesis of various other PNP. METHODS The presence of the RAGE ligand Nepsilon-Carboxymethyllysine (CML… CONTINUE READING