Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal endoderm, whereas Wnt/β-catenin signaling promotes differentiation into visceral endoderm.

@article{Chuykin2013ActivationOT,
  title={Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal endoderm, whereas Wnt/β-catenin signaling promotes differentiation into visceral endoderm.},
  author={Ilya Chuykin and Herbert Schulz and Kaomei Guan and Michael Bader},
  journal={Journal of cell science},
  year={2013},
  volume={126 Pt 1},
  pages={128-38}
}
During early mammalian development, primitive endoderm (PrE) is specified and segregated away from the pluripotent epiblast. At a later developmental stage, PrE forms motile parietal endoderm (PE) lying proximal to the trophectoderm, and visceral endoderm (VE) that contacts the developing epiblast and extraembryonic ectoderm. Mouse extraembryonic endoderm (XEN) cells were isolated and became widely used to study signals governing lineage specification. Rat XEN cell lines have also been derived… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Similar Papers

Loading similar papers…