Activation of the PKR/eIF2α signaling cascade inhibits replication of Newcastle disease virus

@inproceedings{Zhang2013ActivationOT,
  title={Activation of the PKR/eIF2α signaling cascade inhibits replication of Newcastle disease virus},
  author={Shilei Zhang and Yingjie Sun and Hongjun Chen and Yabin Dai and Yuan Zhan and Shengqing Yu and Xu-sheng Qiu and Lei Tan and Cuiping Song and Chan Ding},
  booktitle={Virology Journal},
  year={2013}
}
Newcastle Disease virus (NDV) causes severe and economically significant disease in almost all birds. However, factors that affect NDV replication in host cells are poorly understood. NDV generates long double-stranded RNA (dsRNA) molecules during transcription of single-stranded genomic RNA. Protein kinase R (PKR) is activated by dsRNA. The aim of this study was to elucidate the role of PKR in NDV infection. NDV infection led to the activation of dsRNA-dependent PKR and phosphorylation of its… CONTINUE READING
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