Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma

@article{Huang2008ActivationOT,
  title={Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma},
  author={Yan Huang and K. Y. W. Hua and Xianrong Zhou and Hongyan Jin and Xiaojun Chen and Xin Lu and Yinhua Yu and Xiliang Zha and You-ji Feng},
  journal={Cell Research},
  year={2008},
  volume={18},
  pages={780-791}
}
There is evidence to suggest that follicle-stimulating hormone (FSH) can facilitate the neovascularization of ovarian cancers by increasing vascular endothelial growth factor (VEGF) expression in cancer cells, although the underlying molecular mechanism of this process is not well known. Therefore, we investigated the effect of FSH on VEGF expression in the ovarian cancer cell lines SKOV-3 and ES-2. Treatment with FSH significantly increased VEGF expression in a dose- and time-dependent manner… CONTINUE READING

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