Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells.

@article{Ohashi2009ActivationOT,
  title={Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells.},
  author={Emi Ohashi and Takahiko Kogai and Hiroyuki Kagechika and Gregory A. Brent},
  journal={Cancer research},
  year={2009},
  volume={69 8},
  pages={3443-50}
}
Iodide uptake in the thyroid and breast is mediated by the sodium/iodide symporter (NIS). NIS activation is used for radioiodide imaging and therapeutic ablation of thyroid carcinoma. NIS is expressed in >70% of breast cancers but at a level insufficient for radioiodine treatment. All-trans retinoic acid (tRA) induces NIS gene expression and functional iodide uptake in human breast cancer cell lines and mouse breast cancer models. tRA usually regulates gene expression by direct interaction of… CONTINUE READING

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Iodide transport and breast cancer.

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Retinoic acid stimulation of the Sodium/Iodide Symporter in MCF-7 RA Induces NIS by PI3 Kinase Activation in MCF-7 Cells www.aacrjournals.org 3449

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