Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.

@article{Wang2010ActivationOT,
  title={Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.},
  author={Xiu Jun Wang and John D. Hayes and Larry G. Higgins and C. R. Wolf and Albena T Dinkova-Kostova},
  journal={Chemistry & biology},
  year={2010},
  volume={17 1},
  pages={
          75-85
        }
}
Transcription factor NF-E2 p45-related factor 2 (Nrf2) mediates adaptation to oxidants and electrophiles through up-regulating genes that contain antioxidant response elements (AREs) in their promoters. Using the stably transfected human AREc32 reporter cell line, we found that copper and other transition metals enhanced induction of ARE-driven luciferase by 2-tert-butyl-1,4-hydroquinone (tBHQ) as a result of increased oxidation to 2-tert-butyl-1,4-benzoquinone (tBQ). Following exposure to tBHQ… CONTINUE READING
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