Activation of the NF-κB pathway by Caspase 8 and its homologs

@article{Chaudhary2000ActivationOT,
  title={Activation of the NF-κB pathway by Caspase 8 and its homologs},
  author={Preet M. Chaudhary and Michael T. Eby and Alan Jasmin and Arvind Kumar and Li Liu and Leroy Hood},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={4451-4460}
}
Caspase 8 is the most proximal caspase in the caspase cascade and has been known for its role in the mediation of cell death by various death receptors belonging to the TNFR family. We have discovered that Caspase 8 can activate the NF-κB pathway independent of its activity as a pro-apoptotic protease. This property is localized to its N-terminal prodomain, which contains two homologous death effector domains (DEDs). Caspase 10 and MRIT, two DEDs-containing homologs of Caspase 8, can similarly… CONTINUE READING

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