Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAFV600E Melanoma

  title={Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAFV600E Melanoma},
  author={Shira Y. Wieder and Madhavika N. Serasinghe and Julie C. Sung and Daniel C. Choi and Miriam B. Birge and Jonathan L. Yao and Emily M Bernstein and Julide Tok Celebi and Jerry Edward Chipuk},
  booktitle={The Journal of investigative dermatology},
The shape of the mitochondrial network results from the cumulative activity of two opposing processes: fusion and fission (Mishra and Chan, 2014). These processes collaborate to ensure homeostatic maintenance of mitochondrial function, cellular bioenergetics, and commitment to mitosis (Nasrallah and Horvath, 2014). While the contributions of aberrant mitochondrial dynamics in neurodegenerative and cardiometabolic diseases are established, little is known about the contribution of mitochondrial… CONTINUE READING
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