Activation of the MCM helicase from the thermophilic archaeon, Thermoplasma acidophilum by interactions with GINS and Cdc6-2

@article{Ogino2014ActivationOT,
  title={Activation of the MCM helicase from the thermophilic archaeon, Thermoplasma acidophilum by interactions with GINS and Cdc6-2},
  author={Hiromi Ogino and S. Ishino and Gyri Teien Haugland and Nils-K{\aa}re Birkeland and Daisuke Kohda and Yoshizumi Ishino},
  journal={Extremophiles},
  year={2014},
  volume={18},
  pages={915-924}
}
In DNA replication studies, the mechanism for regulation of the various steps from initiation to elongation is a crucial subject to understand cell cycle control. The eukaryotic minichromosome maintenance (MCM) protein complex is recruited to the replication origin by Cdc6 and Cdt1 to form the pre-replication complex, and participates in forming the CMG complex formation with Cdc45 and GINS to work as the active helicase. Intriguingly, Thermoplasma acidophilum, as well as many other archaea… CONTINUE READING

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Proceedings of the National Academy of Sciences of the United States of America • 2006
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