Activation of the MAP Kinase Pathway by FGF-1 Correlates with Cell Proliferation Induction While Activation of the Src Pathway Correlates with Migration

@article{Lavallee1998ActivationOT,
  title={Activation of the MAP Kinase Pathway by FGF-1 Correlates with Cell Proliferation Induction While Activation of the Src Pathway Correlates with Migration },
  author={Theresa M Lavallee and Igor A. Prudovsky and Grainne A. McMahon and Xiaoguo Hu and Thomas Maciag},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={141},
  pages={1647 - 1658}
}
FGF regulates both cell migration and proliferation by receptor-dependent induction of immediate-early gene expression and tyrosine phosphorylation of intracellular polypeptides. Because little is known about the disparate nature of intracellular signaling pathways, which are able to discriminate between cell migration and proliferation, we used a washout strategy to examine the relationship between immediate-early gene expression and tyrosine phosphorylation with respect to the potential of… CONTINUE READING

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