Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha.

@article{Krachmarov1996ActivationOT,
  title={Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha.},
  author={Chavdar P. Krachmarov and L G Chepenik and S Barr-Vagell and Kamel Khalili and Edward Merle Johnson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 24},
  pages={14112-7}
}
JC virus is activated to replicate in glial cells of many AIDS patients with neurological disorders. In human glial cells, the human immunodeficiency virus 1 (HIV-1) Tat protein activates the major late promoter of JC virus through a Tat-responsive DNA element, termed upTAR, which is a recognition site for cellular Pur alpha, a sequence-specific single-stranded DNA binding protein implicated in cell cycle control of DNA replication and transcription. Tat interacts with two leucine-rich repeats… CONTINUE READING

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