Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity.

  title={Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity.},
  author={Hideki Watanabe and Olivier Gaide and Virginie P{\'e}trilli and Fabio Martinon and Emmanuel Contassot and St{\'e}phanie Roques and Jean Alain Kummer and J. -M. Tschopp and Lars Einar French},
  journal={The Journal of investigative dermatology},
  volume={127 8},
The inflammasome is a cytosolic protein complex regulating the activation of caspase-1, which cleaves the pro-inflammatory cytokines IL-1beta and IL-18 into their active form. The inflammasome is composed of a NACHT-, LRR- and pyrin (NALP) family member that acts as a sensor for danger signals and the adaptor protein apoptosis-associated speck-like protein containing a CARD domain (ASC), which allows the recruitment of caspase-1 in the complex. In the skin, exposure to contact sensitizers (CS… CONTINUE READING


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