Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress*

  title={Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress*},
  author={H. Kaneto and G. Xu and K. H. Song and K. Suzuma and S. Bonner-Weir and A. Sharma and G. Weir},
  journal={The Journal of Biological Chemistry},
  pages={31099 - 31104}
  • H. Kaneto, G. Xu, +4 authors G. Weir
  • Published 2001
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • It is known well that activation of the hexosamine pathway causes insulin resistance, but how this activation influences pancreatic β-cell function remains unclear. In this study, we found that in isolated rat islets adenovirus-mediated overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT), the first and rate-limiting enzyme of the hexosamine pathway, leads to deterioration of β-cell function, which is similar to that found in diabetes. Overexpression of GFAT or treatment… CONTINUE READING
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