Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress*

@article{Kaneto2001ActivationOT,
  title={Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic $\beta$-Cell Function through the Induction of Oxidative Stress*},
  author={Hideaki Kaneto and G. Xu and Kyung-Hee Song and Kiyoshi Suzuma and Susan Bonner-Weir and A. J. Sharma and Gordon C. Weir},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={31099 - 31104}
}
It is known well that activation of the hexosamine pathway causes insulin resistance, but how this activation influences pancreatic β-cell function remains unclear. In this study, we found that in isolated rat islets adenovirus-mediated overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT), the first and rate-limiting enzyme of the hexosamine pathway, leads to deterioration of β-cell function, which is similar to that found in diabetes. Overexpression of GFAT or treatment… Expand
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