Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin

  title={Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin},
  author={Emma J. Williams and Josie Furness and Frank S. Walsh and Patrick Doherty},
Cell contact-dependent neurite outgrowth stimulated by CAMs requires activation of a second messenger pathway that requires the function of a tyrosine kinase upstream from calcium influx into neurons. In the present study, we present evidence that implicates activation of the fibroblast growth factor receptor (FGFR) in the pathway underlying neurite outgrowth stimulated by L1, N-CAM, and N-cadherin. We have identified a CAM homology domain in the FGF family of receptors and show that antibodies… CONTINUE READING
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