Activation of the Endosome-Associated Ubiquitin Isopeptidase AMSH by STAM, a Component of the Multivesicular Body-Sorting Machinery

@article{McCullough2006ActivationOT,
  title={Activation of the Endosome-Associated Ubiquitin Isopeptidase AMSH by STAM, a Component of the Multivesicular Body-Sorting Machinery},
  author={John McCullough and Paula E. Row and {\'O} Lorenzo and Mary Doherty and Robert J Beynon and Michael J Clague and Sylvie Urb{\'e}},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={160-165}
}
AMSH is an endosomal ubiquitin isopeptidase that can limit EGF receptor downregulation . It directly binds to the SH3 domain of STAM, which is constitutively associated with Hrs, a component of clathrin-coated structures on endosomes. This clathrin coat has been implicated in the recruitment of ubiquitinated growth factor receptors prior to their incorporation into internal vesicles of the multivesicular body (MVB) , through the concerted action of ESCRT complexes I, II, and III . We now show… CONTINUE READING