Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks.

@article{Mrtensson2003ActivationOT,
  title={Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks.},
  author={Susanne M{\aa}rtensson and Jonas O Nygren and Neil Osheroff and Ola Hammarsten},
  journal={Radiation research},
  year={2003},
  volume={160 3},
  pages={291-301}
}
The DNA-dependent protein kinase (DNA-PK) is a DNA-end activated protein kinase that is required for efficient repair of DNA double-strand breaks (DSBs) and for normal resistance to ionizing radiation. DNA-PK is composed of a DNA-binding subunit, Ku, and a catalytic subunit, DNA-PKcs (PRKDC). We have previously shown that PRKDC is activated when the enzyme interacts with the terminal nucleotides of a DSB. These nucleotides are often damaged when DSBs are introduced by anticancer agents and… CONTINUE READING