Activation of the Cpx regulon destabilizes the F plasmid transfer activator, TraJ, via the HslVU protease in Escherichia coli.

@article{LauWong2008ActivationOT,
  title={Activation of the Cpx regulon destabilizes the F plasmid transfer activator, TraJ, via the HslVU protease in Escherichia coli.},
  author={Isabella C Lau-Wong and Troy Locke and Michael J. Ellison and Tracy L. Raivio and Laura S. Frost},
  journal={Molecular microbiology},
  year={2008},
  volume={67 3},
  pages={516-27}
}
The Escherichia coli CpxAR two-component signal transduction system senses and responds to extracytoplasmic stress. The cpxA101* allele was previously found to reduce F plasmid conjugation by post-transcriptional inactivation of the positive activator TraJ. Microarray analysis revealed upregulation of the protease-chaperone pair, HslVU, which was shown to degrade TraJ in an E. coli C600 cpxA101* background. Double mutants of cpxA101* and hslV or hslU restored TraJ and F conjugation to wild-type… CONTINUE READING
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