Activation of the CXCR4 chemokine receptor enhances biological functions associated with B16 melanoma liver metastasis.

@article{Mendt2017ActivationOT,
  title={Activation of the CXCR4 chemokine receptor enhances biological functions associated with B16 melanoma liver metastasis.},
  author={Mayela Mendt and Jose E. Cardier},
  journal={Melanoma research},
  year={2017},
  volume={27 4},
  pages={
          300-308
        }
}
The CXCR4 chemokine receptor plays an essential role in the homing of cells to organs expressing its ligand, CXCL12. CXCR4 expressed on tumor cells might regulate their traffic during metastasis. Here, we investigated whether the activation of CXCR4 on B16 murine melanoma cells regulates biological functions associated with metastasis, in vitro and in vivo. Flow cytometry and PCR analysis showed that B16 constitutively expresses high levels of CXCR4 (CXCR4-B16). Biological assays showed that… CONTINUE READING
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