Activation of the CFTR Cl- channel by trimethoxyflavone in vitro and in vivo.

  title={Activation of the CFTR Cl- channel by trimethoxyflavone in vitro and in vivo.},
  author={Horst Fischer and Beate Illek},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  volume={22 5-6},
The flavone apigenin has been previously selected as a potent pharmacological activator of the CFTR Cl(-) channel, however, its utility for the activation of CFTR in vivo is expected to be limited because flavonoids are readily metabolized. We therefore investigated the poorly metabolizable methylether of apigenin, 5,7,4'-trimethoxyflavone (TMF) as a CFTR activator using transepithelial short-circuit current measurements, whole cell and single cell patch clamp techniques, and nasal potential… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 19 references

Methylated flavonoids have greatly improved intestinal absorption and metabolic stability.

Drug metabolism and disposition: the biological fate of chemicals • 2006

Rescue of DF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules

PDJ Grootenhuis, P Negulescu
Am J Physiol Lung Cell Mol Physiol 2006;290:L1117- • 2006

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