Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cells

Chemotherapeutic agents and γ-irradiation used in the treatment of brain tumors, the most common solid tumors of childhood, have been shown to act primarily by inducing apoptosis. Here, we report that activation of the CD95 pathway was involved in drug- and γ-irradiation-induced apoptosis of medulloblastoma and glioblastoma cells. Upon treatment CD95 ligand… CONTINUE READING