Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett’s Esophagus

@article{Castillo2011ActivationOT,
  title={Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett’s Esophagus},
  author={Daniel Albert Evangelista Castillo and S{\`o}nia Puig and Ma Luisa Iglesias and Agustin I. Seoane and Carme de Bol{\'o}s and V Cristian Munitiz and Pascual Parrilla and L. Sans Comerma and Richard Poulsom and Kausilia K Krishnadath and Luis Santiago Azuara Grande and M Pera},
  journal={Journal of Gastrointestinal Surgery},
  year={2011},
  volume={16},
  pages={227-237}
}
BackgroundA human model of gastroesophageal reflux disease was used to examine the contribution of a non-specialized columnar type of metaplasia (NSCM) and key molecular events (BMP4 and CDX2) in the development of Barrett’s esophagus.MethodsBiopsies of the remnant esophagus from 18 patients undergoing esophagectomy with gastric preservation were taken at 6–36-month intervals postoperatively and examined for activation of the BMP pathway (BMP4/P-Smad 1/5/8) and CDX2 and CDX1 expression by… CONTINUE READING
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