Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells


The mechanism of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance in cancer cells is not fully understood. Here, we show that the Akt survival pathway plays an important role in TRAIL resistance in human cancer cells. Specifically, we found that TRAIL treatment activates the Akt survival pathway and that inhibition of this pathway… (More)
DOI: 10.1371/journal.pone.0010226


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