Activation of the Akt/protein kinase B signaling pathway is associated with granulosa cell survival.

@article{Johnson2001ActivationOT,
  title={Activation of the Akt/protein kinase B signaling pathway is associated with granulosa cell survival.},
  author={Alan L Johnson and Jamie T. Bridgham and Jacob A Swenson},
  journal={Biology of reproduction},
  year={2001},
  volume={64 5},
  pages={1566-74}
}
Follicles from the hen ovary that have been selected into the preovulatory hierarchy are committed to ovulation and rarely become atretic under normal physiological conditions. In part, this is attributed to the resistance of the granulosa layer to apoptosis. The present studies were conducted to evaluate the role of the phosphatidylinositol (PI) 3-kinase/Akt signaling pathway in hen granulosa cell survival and, by implication, follicle viability. Cloning of the chicken akt2 homologue revealed… CONTINUE READING
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