Activation of the Ah Receptor Signaling Pathway by Prostaglandins

  title={Activation of the Ah Receptor Signaling Pathway by Prostaglandins},
  author={Shawn D. Seidel and G. Winters and W. Rogers and M. Ziccardi and V. Li and B. Keser and M. Denison},
  journal={Journal of Biochemical and Molecular Toxicology},
  • Shawn D. Seidel, G. Winters, +4 authors M. Denison
  • Published 2001
  • Chemistry, Medicine
  • Journal of Biochemical and Molecular Toxicology
  • The aryl hydrocarbon receptor (AhR) is a ligand‐dependent transcription factor that mediates many of the biological and toxicological actions of a diverse range of chemicals, including the environmental contaminant 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD, dioxin). Although no endogenous physiological ligand for the AhR has yet been described, numerous studies support the existence of such a ligand(s). Here we have examined the ability of prostaglandins and related chemicals to activate the… CONTINUE READING
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