Activation of the Ah Receptor Signaling Pathway by Prostaglandins

@article{Seidel2001ActivationOT,
  title={Activation of the Ah Receptor Signaling Pathway by Prostaglandins},
  author={Shawn D. Seidel and Gidon Winters and William John Rogers and Michael H Ziccardi and V Li and Bart J G Keser and Michael S. Denison},
  journal={Journal of Biochemical and Molecular Toxicology},
  year={2001},
  volume={15}
}
The aryl hydrocarbon receptor (AhR) is a ligand‐dependent transcription factor that mediates many of the biological and toxicological actions of a diverse range of chemicals, including the environmental contaminant 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD, dioxin). Although no endogenous physiological ligand for the AhR has yet been described, numerous studies support the existence of such a ligand(s). Here we have examined the ability of prostaglandins and related chemicals to activate the… 
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TLDR
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Endogenous Functions of the Aryl Hydrocarbon Receptor (AHR): Intersection of Cytochrome P450 1 (CYP1)-metabolized Eicosanoids and AHR Biology*
TLDR
It is proposed that many endogenous and exogenous cellular stimuli lead to (i) AHR-dependent CYP1-dependent eicosanoid synthesis and degradation and (ii) A HR-dependent cytochrome P450-independent (eicOSanoid-dependent and -independent) responses.
Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.
TLDR
Evidence for the structural promiscuity of AhR ligand binding is described and the current state of knowledge with regards to the activation of the AhR signaling pathway by naturally occurring exogenous and endogenous ligands is discussed.
Metabolic fate of the Ah receptor ligand 6-formylindolo[3,2-b]carbazole.
TLDR
Tryptophan photoproducts fit into a model in which the ligand-activated AhR signaling is autoregulated by the induced metabolic enzymes, and are found to take part in the metabolic degradation of FICZ.
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