Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection

@article{Fan2015ActivationOT,
  title={Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection},
  author={Xue-yu Fan and Chan Tian and Hui Wang and Yin Xu and Ke Ren and Bao-yun Zhang and Chen Gao and Qi Shi and Ge Meng and Lu-bin Zhang and Yangjing Zhao and Qi-Xiang Shao and Xiao-Ping Dong},
  journal={Scientific Reports},
  year={2015},
  volume={5}
}
  • Xue-yu Fan, Chan Tian, +10 authors Xiao-Ping Dong
  • Published 2015
  • Biology, Medicine
  • Scientific Reports
  • AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation of the macroautophagic system in scrapie-infected experimental rodents and in certain human prion diseases, in which the essential negative regulator mTOR is severely inhibited. In this study, AMPK and ULK1 in the brains of hamsters infected with scrapie strain 263 K and in the scrapie-infected cell line SMB-S15 were… CONTINUE READING

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