Activation of the AMP-activated protein kinase reduces inflammatory nociception.

  title={Activation of the AMP-activated protein kinase reduces inflammatory nociception.},
  author={Otto Quintus Russe and Christine V. M{\"o}ser and Katharina L. Kynast and Tanya S King and Heike Stephan and Gerd 7 Geisslinger and Ellen Niederberger},
  journal={The journal of pain : official journal of the American Pain Society},
  volume={14 11},
UNLABELLED The activation of the adenosine monophosphate (AMP)-activated kinase (AMPK) has been associated with beneficial effects such as improvement of hyperglycemic states in diabetes as well as reduction of obesity and inflammatory processes. Recent studies provide evidence for a further role of AMPK in models of acute and neuropathic pain. In this study, we investigated the impact of AMPK on inflammatory nociception. Using 5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide (AICAR) and… CONTINUE READING
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