Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD).

Abstract

BACKGROUND Autosomal recessive polycystic kidney disease (ARPKD) [MIM 263200] belongs to a group of congenital hepatorenal fibrocystic syndromes and is caused by mutations in the PKHD1 gene encoding the multidomain protein fibrocystin/polyductin (FPC). The serine-threonine kinase mammalian target of rapamycin (mTOR) is one of the most important gate-keepers… (More)
DOI: 10.1093/ndt/gfn744

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